Leave the railroad station by the marble steps outside the main doors, or by the easy-to-miss (and conveniently stair-free) side exit if you have rolling luggage, a stroller, or a wheelchair.
When you reach the wide fondamenta or pavement in front of the station, turn left.
Walk past the Scalzi Church and the Scalzi Bridge toward the Lista di Spagna (a busy pedestrian thoroughfare).
Continue down the Lista di Spagna for a short distance. The Hotel Adriatico's entrance is on your left at no. 224, just beyond a shop with a red awning. (Look for a hanging round sign above the doorway.)
Look for the Calatrava Bridge (a.k.a. the Ponte della Costituzione). It's the large modern bridge at the northeast corner of the square, next to the Hotel Santa Chiara.
Cross the bridge and continue straight ahead, past the large building on your left, to the train station.
From the station, follow the directions above.
Take a shuttle bus, a taxi, or the People Mover to the Piazzale Roma.
Follow the directions above.
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