The Hotel Hesperia is a one of Venice's most highly-rated three-star hotels, and its location is appealing:
The hotel overlooks the Canareggio Canal, one short bridge away from the Guglie stop of the Alilagun Linea Arancio airport boat.
It's also within an easy walk of the Santa Lucia railroad station, with no bridges to cross.
As you leave the waterbus platform, turn right.
Walk along the fondamenta or sidewalk, past the Gam Gam restaurant, to the Ponte delle Guglie bridge.
Cross the bridge.
On the other side of the Guglie bridge, turn right and walk for a minute or two. The Hesperia is about 200 meters from the bridge, next to the canal.
For a video preview of your walk, click below:
Leave the railroad station by the marble steps outside the main doors, or by the easy-to-miss (and conveniently stair-free) side exit near Platform 1.
When you reach the wide fondamenta or pavement in front of the station, turn left.
Walk past the Scalzi Church and the Scalzi Bridge toward the Lista di Spagna (a busy pedestrian thoroughfare).
Continue down the Lista di Spagna, through the Campo San Geremia (you'll see a large domed church on your right), and on to the Ponte delle Guglie Bridge.
Do not cross the bridge. Instead, turn left and walk along the canal until you reach the Hotel Hesperia. (The entire walk from the station shouldn't take longer than 10 minutes.)
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